IL-12B p40 Polyclonal Antibody

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

The IL-12B p40 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IL-12B p40 protein in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and reliability.

IL-12B p40 is a subunit of the interleukin-12 (IL-12) cytokine, which plays a crucial role in the regulation of immune responses. It is involved in the activation and differentiation of T cells, natural killer cells, and macrophages, thereby influencing the adaptive and innate immune systems. Dysregulation of IL-12B p40 has been implicated in various pathological conditions, including autoimmune diseases, infectious diseases, and cancer.

The IL-12B p40 Polyclonal Antibody exhibits exceptional specificity, binding exclusively to IL-12B p40 protein without cross-reactivity to other related proteins. This ensures accurate and reliable detection of IL-12B p40 in complex biological samples. The antibody also demonstrates high sensitivity, enabling the detection of low levels of IL-12B p40 with minimal sample input.

This antibody has been extensively validated using various experimental techniques, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). It has shown excellent performance in these assays, consistently producing robust and specific signals.

Furthermore, the IL-12B p40 Polyclonal Antibody has been manufactured under stringent quality control standards to ensure batch-to-batch consistency and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

In summary, the IL-12B p40 Polyclonal Antibody is a highly reliable and sensitive tool for the detection and quantification of IL-12B p40 protein. Its exceptional specificity, sensitivity, and validated performance make it an invaluable asset for researchers studying the role of IL-12B p40 in various biological processes and disease states.