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ELK Biotechnology
SKU(재고 관리 코드):ES9332
INP5E Rabbit Polyclonal Antibody
INP5E Rabbit Polyclonal Antibody
INP5E Rabbit Polyclonal Antibody
Overview
| Product name: | INP5E rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 490-570 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 70kD |
| GeneID（Human）: | 56623 |
| Human Swiss-Prot No: | Q9NRR6 |
| Cellular localization: | Cytoplasm, cytoskeleton, cilium axoneme . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, ruffle . Cytoplasm . Nucleus . Peripheral membrane protein associated with Golgi stacks. . |
| Background: | The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016], |
| Species Reactivity: | Human;Mouse;Rat |
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