IRAK-1(Phospho Ser376) Polyclonal Antibody

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The IRAK-1(Phospho Ser376) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IRAK-1 protein phosphorylated at Ser376. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

The IRAK-1 protein plays a crucial role in the innate immune response by mediating the signaling pathway downstream of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Phosphorylation of IRAK-1 at Ser376 has been implicated in the regulation of its activity and downstream signaling events.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IRAK-1 protein in various biological samples.

The IRAK-1(Phospho Ser376) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimal wastage.

With its exceptional performance and reliability, this antibody is an indispensable tool for researchers studying the role of IRAK-1 phosphorylation in innate immune signaling pathways. It offers valuable insights into the molecular mechanisms underlying immune responses and holds great potential for the development of novel therapeutic strategies targeting IRAK-1 signaling.