IRF-3(Phospho Ser386) Polyclonal Antibody

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The IRF-3(Phospho Ser386) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of phosphorylated serine 386 residue of the interferon regulatory factor 3 (IRF-3) protein. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target epitope.

The interferon regulatory factor 3 (IRF-3) protein plays a crucial role in the regulation of innate immune responses, particularly in the induction of type I interferons. Phosphorylation of serine 386 residue is a key post-translational modification that activates IRF-3 and promotes its nuclear translocation, leading to the transcriptional activation of interferon-stimulated genes.

The IRF-3(Phospho Ser386) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IRF-3 in various sample types.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effectiveness and minimizing wastage. The product is manufactured under strict quality control standards, guaranteeing consistent and reproducible results.

In summary, the IRF-3(Phospho Ser386) Polyclonal Antibody is a valuable tool for researchers studying the role of IRF-3 in innate immune responses. Its high specificity, sensitivity, and versatility make it an ideal choice for a wide range of applications.