IRP-1(Phospho Ser138) Polyclonal Antibody

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct

The IRP-1(Phospho Ser138) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IRP-1 protein phosphorylated at Ser138. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The IRP-1 protein plays a crucial role in the regulation of iron metabolism and homeostasis. Phosphorylation of IRP-1 at Ser138 has been implicated in various cellular processes, including the control of iron uptake, storage, and utilization. Therefore, the ability to accurately measure the phosphorylation status of IRP-1 at Ser138 is of great importance in understanding the intricate mechanisms underlying iron metabolism.

This polyclonal antibody has been extensively validated for its specificity and sensitivity in various experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated IRP-1 and other related proteins, ensuring reliable and accurate results.

The IRP-1(Phospho Ser138) Polyclonal Antibody is supplied as a liquid formulation in a convenient size, allowing for easy handling and storage. It is recommended for use in both basic research and clinical applications, providing valuable insights into the role of IRP-1 phosphorylation in iron metabolism and related diseases.

With its exceptional performance and reliability, the IRP-1(Phospho Ser138) Polyclonal Antibody is an indispensable tool for researchers and clinicians alike, facilitating advancements in the understanding and treatment of iron-related disorders.