JAM3 Polyclonal Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.

The JAM3 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Junctional Adhesion Molecule 3 (JAM3) protein. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards JAM3.

JAM3 is a transmembrane protein that plays a crucial role in cell adhesion and migration processes. It is primarily expressed in endothelial cells and is involved in the regulation of leukocyte trafficking and vascular permeability. The JAM3 Polyclonal Antibody enables researchers to investigate the expression and localization of JAM3 in various tissues and cell types.

This antibody has been rigorously tested and validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The JAM3 Polyclonal Antibody is supplied as a liquid formulation, allowing for easy handling and storage. It is provided in a convenient size, ensuring cost-effectiveness and reducing waste. Each batch of antibody undergoes strict quality control measures to ensure consistency and reproducibility.

Researchers and scientists in the fields of cell biology, immunology, and vascular biology will greatly benefit from the use of the JAM3 Polyclonal Antibody. Its high specificity, sensitivity, and versatility make it an indispensable tool for studying the role of JAM3 in various physiological and pathological processes.