JPH2 Polyclonal Antibody

JPH2 Polyclonal Antibody

The JPH2 polyclonal antibody is a highly specific and sensitive tool for the detection and quantification of junctophilin-2 (JPH2) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human JPH2 protein, followed by purification of the resulting polyclonal antibodies using affinity chromatography.

JPH2 is a key protein that plays a critical role in the formation and maintenance of the junctional complexes between the plasma membrane and the sarcoplasmic reticulum in cardiac and skeletal muscle cells. Dysregulation of JPH2 expression or function has been implicated in various cardiovascular and neuromuscular disorders, including heart failure, arrhythmias, and muscular dystrophy. Therefore, accurate measurement of JPH2 protein levels is essential for understanding the pathophysiology of these diseases and developing effective therapeutic strategies.

The JPH2 polyclonal antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. This antibody recognizes a single band of the expected size (~85 kDa) in Western blot analysis of human, mouse, and rat heart tissue lysates, and shows minimal cross-reactivity with other junctophilin isoforms or unrelated proteins. In addition, this antibody exhibits strong and specific staining of JPH2 protein in cardiac and skeletal muscle tissues in immunohistochemistry and immunofluorescence assays, with minimal background staining.

Overall, the JPH2 polyclonal antibody is a reliable and high-quality reagent for the detection and quantification of JPH2 protein in various biological samples, and is suitable for use in both basic research and clinical applications.