BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1
Source:
Rabbit
Applications:
WB, IHC
Species:
Human
Recommended dilutions:
WB 1:1500-1,000 IHC 1:100-200
Immunogen:
Recombinant Protein
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1mg/ml
Observed band:
45-120kDa
GeneID（Human）:
3827
Human Swiss-Prot No:
P01042
Cellular localization:
Secreted
Background:
Kininogens are inhibitors of thiol proteases; HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL1 is abundantly expressed in neuronal tissues and testes.
