KMT1B Polyclonal Antibody

Histone-lysine N-methyltransferase SUV39H2 is a Histone methyltransferase that specifically trimethylates Lys-9 of histone H3 using monomethylated H3 Lys-9 as substrate. H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 Lys-9 trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 Lys-9 trimethylation. Among its related pathways are Lysine degradation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is EHMT1.

The KMT1B Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of KMT1B protein expression in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

The KMT1B Polyclonal Antibody exhibits a high affinity towards the KMT1B protein, enabling accurate and precise identification of its presence in cells and tissues. It is an ideal choice for researchers and scientists involved in studying the role and function of KMT1B in various biological processes.

This antibody has been extensively validated through rigorous testing procedures, ensuring its consistent performance and reproducibility. It demonstrates minimal cross-reactivity with other proteins, guaranteeing reliable and accurate results.

The KMT1B Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into various experimental protocols. It is compatible with multiple applications, including Western blotting, immunohistochemistry, and immunofluorescence, providing versatility and flexibility in experimental design.

With its exceptional quality and performance, the KMT1B Polyclonal Antibody is an indispensable tool for researchers seeking to unravel the intricate mechanisms underlying KMT1B protein function. Trust in its reliability and specificity to advance your scientific endeavors and contribute to the advancement of knowledge in the field.