Laminin Gamma-2 Polyclonal Antibody

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i. E. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

The Laminin Gamma-2 Polyclonal Antibody is a highly specific and reliable tool for the detection and analysis of Laminin Gamma-2 protein in various biological samples. This antibody has been extensively validated for its exceptional sensitivity and specificity, ensuring accurate and reproducible results.

The Laminin Gamma-2 Polyclonal Antibody is produced using state-of-the-art techniques, guaranteeing high purity and batch-to-batch consistency. It has been rigorously tested for its ability to recognize the Laminin Gamma-2 protein in a variety of experimental conditions, making it suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its superior performance, this antibody enables researchers to investigate the role of Laminin Gamma-2 in various biological processes, such as cell adhesion, migration, and tissue development. Its high affinity and specificity ensure minimal background noise, allowing for precise and accurate quantification of Laminin Gamma-2 expression levels.

The Laminin Gamma-2 Polyclonal Antibody is supplied in a convenient and ready-to-use format, eliminating the need for time-consuming and complex preparation steps. It is provided in a liquid formulation, ensuring easy handling and storage. Each batch is accompanied by a detailed datasheet, providing comprehensive information on the antibody's characteristics, recommended dilutions, and storage conditions.

Choose the Laminin Gamma-2 Polyclonal Antibody for your research needs and unlock new insights into the function and regulation of Laminin Gamma-2 protein. With its exceptional performance and reliability, this antibody is an indispensable tool for any researcher studying Laminin Gamma-2 and its associated biological processes.