LAT(Phospho-Tyr171) Rabbit Polyclonal Antibody

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation| this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.

The LAT(Phospho-Tyr171) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of LAT protein phosphorylated at tyrosine 171. This antibody is produced using high-quality rabbit polyclonal antibodies and is suitable for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The LAT protein is a key signaling molecule involved in T-cell activation and is phosphorylated at multiple tyrosine residues upon T-cell receptor engagement. Phosphorylation of LAT at tyrosine 171 is critical for the recruitment and activation of downstream signaling molecules, including PLCγ1 and Grb2.

This antibody has been extensively validated for specificity and sensitivity, ensuring reliable and reproducible results. It is supplied in a convenient format, with sufficient quantity for multiple experiments.

Overall, the LAT(Phospho-Tyr171) Rabbit Polyclonal Antibody is an essential tool for researchers studying T-cell signaling and activation, and is a valuable addition to any laboratory's antibody collection.