LIMK-1/2(Phospho Thr508/505) Polyclonal Antibody

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cog

The LIMK-1/2 (Phospho Thr508/505) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of LIMK-1 and LIMK-2 proteins phosphorylated at Thr508 and Thr505 residues. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target proteins.

LIMK-1 and LIMK-2 are key regulators of actin cytoskeleton dynamics and play crucial roles in various cellular processes, including cell migration, cell division, and neuronal development. Phosphorylation of LIMK-1 and LIMK-2 at Thr508 and Thr505 residues is known to modulate their activity, leading to alterations in actin filament organization and cellular morphology.

The LIMK-1/2 (Phospho Thr508/505) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated LIMK-1 and LIMK-2 proteins in complex biological samples.

This antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of sample types, including cell lysates, tissue extracts, and purified proteins. The LIMK-1/2 (Phospho Thr508/505) Polyclonal Antibody is suitable for both qualitative and quantitative analysis, making it an indispensable tool for researchers studying actin cytoskeleton dynamics and related cellular processes.

In summary, the LIMK-1/2 (Phospho Thr508/505) Polyclonal Antibody offers exceptional sensitivity, specificity, and versatility for the detection and quantification of phosphorylated LIMK-1 and LIMK-2 proteins. Its reliable performance and ease of use make it an invaluable asset for researchers in the field of cell biology and molecular biology.