LIMK-1 Polyclonal Antibody

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. LIM domain kinase 1 is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. LIM domain kinase 1 also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

The LIMK-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of LIM domain kinase 1 (LIMK-1) protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards LIMK-1.

LIMK-1 is a serine/threonine kinase that plays a crucial role in regulating actin cytoskeleton dynamics and cell motility. It is involved in various cellular processes, including cell migration, adhesion, and invasion. Dysregulation of LIMK-1 has been implicated in several pathological conditions, such as cancer metastasis and neurodegenerative diseases.

The LIMK-1 Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of LIMK-1 protein expression in both normal and diseased tissues.

This antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments without the need for frequent reordering. The LIMK-1 Polyclonal Antibody is manufactured under strict quality control standards, ensuring consistent and reproducible results.

In summary, the LIMK-1 Polyclonal Antibody is a valuable tool for researchers studying the role of LIMK-1 in various biological processes and diseases. Its high specificity, sensitivity, and ease of use make it an ideal choice for reliable and accurate detection of LIMK-1 protein expression.