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ELK Biotechnology
SKU(재고 관리 코드):ES10860
LIRB3 Rabbit Polyclonal Antibody
LIRB3 Rabbit Polyclonal Antibody
LIRB3 Rabbit Polyclonal Antibody
Overview
| Product name: | LIRB3 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from part region of human protein |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 69kD |
| GeneID（Human）: | 11025 |
| Human Swiss-Prot No: | O75022 |
| Cellular localization: | Cell membrane; Single-pass type I membrane protein. |
| Background: | LILRB3 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Leukocyte Immunoglobulin Like Receptor B3 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Species Reactivity: | Human;Mouse |
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