MAFK Polyclonal Antibody

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.

The MADCA Polyclonal Antibody is a highly specific and reliable tool for the detection and quantification of MADCA (Methylmalonic Acidemia with Homocystinuria) in various biological samples. This antibody has been meticulously developed and validated to ensure exceptional performance and accuracy in research and diagnostic applications.

The MADCA Polyclonal Antibody exhibits a high affinity towards MADCA, enabling precise and sensitive detection even at low concentrations. It has been rigorously tested against a wide range of sample types, including serum, plasma, and tissue lysates, ensuring its versatility and suitability for diverse experimental setups.

This antibody is produced using state-of-the-art techniques, guaranteeing batch-to-batch consistency and reproducibility. It has undergone stringent quality control measures to ensure optimal performance, including specificity testing against related compounds to eliminate cross-reactivity.

The MADCA Polyclonal Antibody is supplied as a liquid formulation, allowing for easy handling and convenient storage. It is provided in various sizes to accommodate different experimental needs. The antibody is ready-to-use, eliminating the need for time-consuming preparation steps and enabling immediate incorporation into assays.

With its exceptional specificity, sensitivity, and reliability, the MADCA Polyclonal Antibody is an indispensable tool for researchers and clinicians working in the field of MADCA detection and quantification. Its superior performance and ease of use make it an ideal choice for a wide range of applications, including biomarker discovery, disease monitoring, and therapeutic development.