1
/
의
1
ELK Biotechnology
SKU(재고 관리 코드):ES9783
MAML2 Rabbit Polyclonal Antibody
MAML2 Rabbit Polyclonal Antibody
MAML2 Rabbit Polyclonal Antibody
Overview
| Product name: | MAML2 rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 10-90 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 127kD |
| GeneID（Human）: | 84441 |
| Human Swiss-Prot No: | Q8IZL2 |
| Cellular localization: | Nucleus speckle . Nuclear, in a punctate manner. |
| Background: | The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p |
| Species Reactivity: | Human;Rat;Mouse; |
Share
