MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor
Applications:
WB;ELISA;IHC
Recommended Dilutions:
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:
The antiserum was produced against synthesized peptide derived from human MTR1A. AA range:191-240
Storage:
Rabbit
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
GeneID（Human）:
4543
Human Swiss-Prot No:
P48039
Cellular localization:
Cell membrane; Multi-pass membrane protein.
Background:
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008],
Immunofluorescence analysis of HepG2 cells, using MTR1A Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).