Met(Phospho Tyr1003) Polyclonal Antibody

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

The Met(Phospho Tyr1003) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Met protein phosphorylated at tyrosine 1003. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

The Met protein, also known as hepatocyte growth factor receptor (HGFR), plays a crucial role in various cellular processes, including cell growth, survival, and migration. Phosphorylation of Met at tyrosine 1003 is a key event in the activation of downstream signaling pathways, leading to the regulation of important cellular functions.

This polyclonal antibody is raised in rabbits using a synthetic peptide corresponding to the phosphorylated tyrosine 1003 region of the Met protein. It has been extensively validated for specificity and sensitivity through various experimental approaches, including Western blotting, immunoprecipitation, and immunofluorescence.

The Met(Phospho Tyr1003) Polyclonal Antibody exhibits high affinity and selectivity towards the phosphorylated form of Met at tyrosine 1003, making it an ideal tool for studying the activation and regulation of Met signaling pathways. It provides researchers with a reliable and accurate means to investigate the role of Met in various physiological and pathological processes, such as cancer development, metastasis, and drug resistance.

With its exceptional performance and robustness, the Met(Phospho Tyr1003) Polyclonal Antibody is a valuable asset for scientists and researchers working in the fields of cell biology, molecular biology, cancer research, and drug discovery. Its application extends to both basic research and clinical studies, offering insights into the molecular mechanisms underlying disease progression and potential therapeutic targets.

Order your Met(Phospho Tyr1003) Polyclonal Antibody today and unlock the potential of Met signaling pathway analysis with confidence and precision.