Neu(Phospho Tyr1112) Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

The Neu(Phospho Tyr1112) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of Neu protein phosphorylated at Tyr1112. This antibody is produced using advanced immunization techniques, resulting in a high affinity and specificity towards the phosphorylated form of Neu at Tyr1112.

The Neu protein, also known as ErbB2 or HER2, is a receptor tyrosine kinase that plays a crucial role in cell growth, differentiation, and survival. Dysregulation of Neu signaling has been implicated in various human cancers, making it an important target for therapeutic interventions.

The phosphorylation of Neu at Tyr1112 has been shown to be critical for its activation and downstream signaling. The Neu(Phospho Tyr1112) Polyclonal Antibody recognizes specifically the phosphorylated form of Neu at Tyr1112, enabling researchers to study the activation status of Neu in various cellular contexts.

This antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits minimal cross-reactivity with non-phosphorylated Neu and other related proteins, ensuring accurate and reliable results.

The Neu(Phospho Tyr1112) Polyclonal Antibody is supplied as a liquid formulation, ready to use for immediate experimentation. It is provided in a convenient size and quantity, ensuring cost-effectiveness and minimizing wastage.

In summary, the Neu(Phospho Tyr1112) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of phosphorylated Neu at Tyr1112. Its exceptional sensitivity and specificity make it an invaluable asset for researchers studying the role of Neu signaling in cancer and other diseases.