Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human NRG3. AA range:311-360
Storage:
Rabbit
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
80kD
GeneID（Human）:
10718
Human Swiss-Prot No:
P56975
Cellular localization:
[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane ; Single-pass type I membrane protein . Does not seem to be active. .; [Neuregulin-3]: Secreted .; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Isoform 3 is also proteolytically released as a soluble form.
Background:
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcri
Western Blot analysis of mouse brain, K562 cells using Neuregulin-3 Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
Western Blot analysis of MOUSE-BRAIN cells using Neuregulin-3 Polyclonal Antibody diluted at 1:1000. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
Immunohistochemical analysis of paraffin-embedded mouse-brain, antibody was diluted at 1:200
Western Blot analysis of mouse-heart mouse-brain mouse-lung using Neuregulin-3 Polyclonal Antibody diluted at 1:800. Secondary antibody(catalog#:RS0002) was diluted at 1:20000