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Dima Biotech

PME100960

Human IFNB Protein, hFc Tag

Human IFNB Protein, hFc Tag

Size
Target
Uniprot ID
PRODUCT DATA
TARGET

SYNONYMS

IFB;IFF;IFN-beta;IFNB
DESCRIPTION

Recombinant human IFNB protein with C-terminal human Fc tag
DELIVERY

Under development
UNIPROT ID

P01574
EXPRESSION HOST

HEK293
TAG

C-Human Fc Tag
MOLECULAR CHARACTERIZATION

IFNB(Met22-Asn187) hFc(Glu99-Ala330)
MOLECULAR WEIGHT

The protein has a predicted molecular mass of 43.6 kDa after removal of the signal peptide.
PURITY

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
FORMULATION & RECONSTITUTION

Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
STORAGE & SHIPPING

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
BACKGROUND

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
USAGE

Research use only
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