| TARGET | |
|---|---|
| SYNONYMS |
BTLA;D272 |
| DESCRIPTION |
Recombinant mouse BTLA protein with C-terminal mFc tag |
| DELIVERY |
In Stock |
| UNIPROT ID |
Q7TSA3 |
| EXPRESSION HOST |
HEK293 |
| TAG |
C-Mouse Fc Tag |
| MOLECULAR CHARACTERIZATION |
Mouse BTLA(Glu30-Pro176) mFc(Pro99-Lys330) |
| MOLECULAR WEIGHT |
The protein has a predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is approximately 55-70 kDa due to glycosylation. |
| PURITY |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):PME100525
Mouse BTLA Protein, mFc Tag
Mouse BTLA Protein, mFc Tag
PRODUCT DATA
IMAGES
Figure 1. Mouse BTLA Protein, mFc Tag on SDS-PAGE under reducing condition.
