| TARGET | |
|---|---|
| SYNONYMS |
CD38, T10, cADPr hydrolase 1 |
| DESCRIPTION |
Recombinant human CD38 protein with C-terminal human Fc tag |
| DELIVERY |
In Stock |
| UNIPROT ID |
P28907 |
| EXPRESSION HOST |
HEK293 |
| TAG |
C-Human Fc tag |
| MOLECULAR CHARACTERIZATION |
CD38(Val43-Ile300) hFc(Glu99-Ala330) |
| MOLECULAR WEIGHT |
The protein has a predicted molecular mass of 56.0 kDa after removal of the signal peptide.The apparent molecular mass of CD38-hFc is approximately 70-100 kDa due to glycosylation. |
| PURITY |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia. |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):PME100530
Human CD38 Protein, hFc Tag
Human CD38 Protein, hFc Tag
PRODUCT DATA
IMAGES
Figure 1. Human CD38, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human CD38, hFc tagged protein (PME100530) can bind anti-CD38 antibody, Rabbit mAb (clone:DM30) in a linear range of 0.64-80 ng/ml.
