| TARGET | |
|---|---|
| SYNONYMS |
CD159A;NKG2;NKG2A |
| DESCRIPTION |
Recombinant Human NKG2A Protein with N-terminal human Fc tag |
| DELIVERY |
In Stock |
| UNIPROT ID |
P26715 |
| EXPRESSION HOST |
HEK293 |
| TAG |
N-Human Fc Tag |
| MOLECULAR CHARACTERIZATION |
hFc(Glu99-Ala330) NKG2A(Pro94-Leu233) |
| MOLECULAR WEIGHT |
The protein has a predicted molecular mass of 42.2 kDa after removal of the signal peptide.The apparent molecular mass of hFc-NKG2A is approximately 35-55 kDa due to glycosylation. |
| PURITY |
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| FORMULATION & RECONSTITUTION |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| STORAGE & SHIPPING |
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| BACKGROUND |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015] |
| USAGE |
Research use only |
Dima Biotech
SKU(재고 관리 코드):PME100851
Human NKG2A Protein, hFc Tag
Human NKG2A Protein, hFc Tag
PRODUCT DATA
IMAGES
Figure 1. Human NKG2A Protein, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human NKG2A Protein, hFc Tag (PME100851) can bind Anti-NKG2A antibody(DMC298), IgG1 Chimeric mAb in a linear range of 3.20–80 ng/mL.
