DHX8 polyclonal antibody

DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX8 (DEAH box polypeptide 8), also known as DHX8, HRH1 or PRP22, contains an arginine- and serine-rich domain (RS domain) that is characteristic of some splicing factors. DDX8 may be targeted to the spliceosome through an interaction involving its RS domain.