GDI1 polyclonal antibody

Rab proteins, a family of Ras-related small GTP-binding proteins, play a key role in regulating intracellular vesicle trafficking. Rab GDP dissociation inhibitor (Rab GDI or GDI3) forms a soluble complex with Rab proteins and thereby prevents the exchange of GDP for GTP. In mammals, there exist two major isoforms, Rab GDI α (also known as XAP-4) and Rab GDI β. While the mammalian Rab GDI β-genes are ubiquitously expressed, the Rab GDI α genes are predominantly brain-specific. Since it is expressed predominantly in neural and sensory tissues, Rab GDI α may serve a specific function in neural signalmtransmission. The gene sequences for the Rab GDI proteins are extremely conserved in evolution, with substantial homology preserved across three eukaryotic kingdoms.