GPR75 polyclonal antibody

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR75 is a 540 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR1 family. Highly expressed in spinal cord and brain, GPR75 is also found at low levels in retinal pigment epithelium. The gene encoding GPR75 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alström syndrome.