PSD-93 polyclonal antibody

The postsynaptic density protein (PSD)-93 and related membrane associated guanylate kinase (MAGUK) proteins assemble signal transduction complexes at sites of cell-cell contact including synapses. PSD-93 (also designated channel associated protein of synapse-110 or chapsyn-110) occurs only at postsynaptic sites in hippocampal neurons. PSD-95 and PSD-93 mediate ion channel clustering in heterologous cells and are believed to cluster and anchor NMDA receptors at the synapse. The glutamate receptor subunit, delta2, binds specifically to PSD-93, which is enriched in Purkinje neuron cell bodies and dendrites. In addition, PSD-93 clusters delta2 when they are coexpressed and they are colocalized at parallel fiber synapses.