SSBP2 polyclonal antibody

The single-stranded-DNA-binding proteins (SSBs) are essential for DNA function in prokaryotic and eukaryotic cells, as well as in mitochondria, bacteria and viruses. SSBP2 (single-stranded DNA binding protein 2), also known as SSDP2, is a 361 amino acid protein that localizes to the nucleus and contains one LisH domain. Expressed ubiquitously, SSBP2 is thought to induce growth arrest in cancer cells and may, therefore, function as a potent tumor suppressor. The gene encoding SSBP2 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Defects in chromosome 5-associated genes are related to the pathogenesis of Cockayne syndrome, familial adenomatous polyposis and Treacher Collins syndrome.