CIB4 polyclonal antibody

CIB4 (calciumand integrin-binding familymember 4) is a 185 amino acid protein thatcontainsthree EF-hand domains. CIB4 is closelyrelated to CIB (CIB has one less EF-hand domain),which isknown to bind to IntegrinαIIβ in platelets and isinvolved in signal transduction. The gene encoding CIB4mapsto human chromosome 2,which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare andmorbid skin deformity, is associatedwithmutationsin the ABCA12 gene,while the lipidmetabolic disordersitosterolemia is associated with defectsin the ABCG5 and ABCG8 genes. Additionally, an extremelyrare recessive genetic disorder, Alströmsyndrome, iscaused bymutationsin the ALMS1 gene,whichmaps to chromosome 2.