RGS17 polyclonal antibody

The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. The human gene that encodes RGS17 (regulator of G protein signaling 17, RGS17) contains 4 exons, spans more than 33 kb and maps to chromosome 6q25.3; the mouse Rgs17 gene maps to chromosome 10 as determined by interspecific backcross mapping. RGS17 is a member of the RZ/A protein family. RZ/A proteins have a simple structure that consists of a conserved amino-terminal cysteine string motif, RGS box and short carboxyl-terminal, which confer GAP activity and the ability to undergo covalent modification and associate with other proteins (at their amino-termini).