RGS20 polyclonal antibody

The regulators of G protein signaling (RGS) proteins inhibit heterotrimeric G protein signaling. RGS proteins work by functioning as GTPase-activating proteins (which increase the GTPase activity of G protein a subunits) thereby driving G proteins into their inactive GDP-bound form. RGS20 is expressed exclusively in brain, with highest levels in the caudate nucleus and temporal lobe. RGS20 belongs to the RZ subfamily because it is highly selectivie for the az subunit on G proteins. However, if protein kinase C phosphorylates the az subunit, the G protein is much less susceptible to RGS20 action. RGS20 directly interacts with the microtubule-destabilizing protein SCG10 (superior cervical ganglia, neural specific 10) and blocks its ability to induce microtubule disassmebly.