STK31 polyclonal antibody

Protein kinases catalyze the post-translational transfer of a phosphate group from ATP to a serine, threonine or tyrosine residue, thereby playing a major role in many intracellular and intercellular signaling cascades. STK31 (Serine/threonine-protein kinase 31) is a 1019 amino acid protein belonging to the protein kinase superfamily. STK31 contains one C-terminal protein kinase domain and one N-terminal Tudor domain, which functions as a protein-protein interaction motif during RNA metabolism or transport. As a testis-specific kinase, STK31 is found in both post-meitoic spermatocytes as well as in mature spermatozoa and is thought to be involved in spermatogensis and/or sperm function. Also, as a result of frequent expression in colorectal, gastric and esophageal cancers, STK31 has been identified as a potential cancer/testis (CT) antigen. There are two named isoforms of STK31 which are produced as a result of an alternative splicing event.