SLC9A5 polyclonal antibody

Na+/H+ exchangers-1–6 (Na+/H+ antiporters, NHE-1–6) are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the secondary active extrusion of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+). Excluding NHE-1, which is ubiquitously expressed, NHE isoforms 2–6 have distinct tissue- and cell type-dependent expression and inhibitiory characteristics by amiloride analogs. Human NHE-5 transcript (solute carrier family 9, isoform-5, SLC9A5) is an 896 amino acid protein that is expressed in brain, testis, spleen and skeletal muscle.