YAF2 polyclonal antibody

Members of the myeloctyomatosis viral oncogene homologue (Myc) family, which include c-Myc, N-Myc and L-Myc, encode transcription factors that play a role in the acceleration of cell cycle progression and cell growth, inhibition of cell differentiation, and initiation of programmed cell death (apoptosis). YY1-associated factor 2, also known as YAF2, is a 180 amino acid protein that binds to c-Myc and inhibits c-Myc-mediated pathways. It also binds to N-Myc, enhancing N-Myc-dependent transcriptional activation. Furthermore, YAF2 interacts with YY1 to antagonize YY1 transactivation of muscle-specific promoters. Localized to the nucleus, YAF2 contains an N-terminal C2-X10-C2 zinc finger and exists as two isoforms.