MYH9 polyclonal antibody

Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of 2 heavy chains (MHC) and 4 light chains (MLC) that interacts with actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Myosin heavy chain 9 can also be designated Myosin IIa, nonmuscle myosin heavy chain IIa, Cellular myosin heavy chain, type A, myosin-9 or NMMHC-IIA. Myosin heavy chain 9 is involved in cell shape, cytokinesis, and specialized functions such as capping and secretion. It is expressed in leukoctyes and in kidney glomeruli. Defects in the MYH9 gene, which encodes myosin heavy chain 9, are linked to Sebastian syndrome (SBS), Fechtner syndrome (FTNS), Alport syndrome with macrothrombocytopenia (APSM), autosomal dominant nonsyndromic sensorineural deafness 17 (DFNA17) and Epstein syndrome (EPS).