PROK1 polyclonal antibody

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation,migration and fenestration in capillary endothelialcells derived from endocrine glands. EG-VEGF possesses a HIF-1 binding site; its expression isinduced by hypoxia and restricted to the steroidogenic glands(ovary,testis, adrenal and placenta). EG-VEGF expression is often complementary to the expression of VEGF,suggesting that these moleculesfunction in a coordinatedmanner. EG-VEGFis an example of a class of highly specificmitogensthat act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner. EG-VEGFis expressed largely in one type of tissue and actsselectively on one type of endothelium. EG-VEGF, possiblythrough binding to a G protein-coupled receptor, resultsin the activation ofMAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation,migration and survival of responsive endothelialcells.