GNG13 polyclonal antibody

In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their α subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Evidence, however, has established an important regulatory role for the βγ subunits. It is becoming increasingly clear that different G protein complexes expressed in different tissues carry structurally distinct members of the γ as well as the α and β subunits, and that preferential associations between members of subunit families increase G protein functional diversity.