CCL11 polyclonal antibody

Eotaxin (also designated eotaxin-1) is a member of the C-C or ∫ family of chemokines which is characterized by a pair of adjacent cysteine residues. Eotaxin was first purified from the bronchoalveolar lavage fluid of guinea pigs challenged with an aerosol allergen, and serves as a potent chemoattractant for eosinophils. Eosinophilia is a prominent feature of several allergic conditions and is thought to be a central event in maladies such as bronchial asthma, dermatitis, conjunctivitis and possibly inflammatory bowel disease. The cognate eotaxin receptor has been identified. Originally described as mouse orphan receptor (MIP-1a receptor-like 2), CKR-3 has been shown to not only serve as the high affinity receptor for eotaxin, but also for RANTES and MCP-3. CKR-3 is expressed on the cell surface of primary eosinophils and does not bind to other members of the C-C or C-X-C family of chemokines. CKR-3 also serves as a co-receptor for a restricted subset of viruses.