KCNE1L polyclonal antibody

KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming å-subunits to form K+ channels with unique characteristics. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNE1L (KCNE1-like), also known as KCNE5, potassium voltage-gated channel subfamily E member 1-like protein or AMMECR2, is a 142 amino acid single-pass type I membrane protein belonging to the potassium channel KCNE family. Defects of the KCNE1L gene have been linked to the cardiac and some neurological abnormalities observed in patients with AMME (Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis) contiguous gene syndrome. KCNE1L is primarily expressed in skeletal muscle, brain, placenta, spinal cord and heart.