LATH polyclonal antibody

The PLUNC family of proteins are encoded by genes which map to chromosome 20 and are thought to play a potential role in the innate immune response in regions of the mouth, nose and lungs. As a member of the PLUNC family, BASE (breast cancer and salivary gland-expressed protein) is a 179 amino acid secreted protein that is named for its expression pattern. Due to its 63% sequence similarity with the related protein, Latherin, it is suggested that BASE is the major protein in sweat secretions and has important surfactant properties that lower surface tension. The expression pattern of BASE in many breast cancer cell lines suggests that it may be an easily accessible diagnostic breast cancer marker. Due to the fact that the gene encoding BASE is highly estrogen-repressed, expression of the gene is most likely dependent on HNF-3α and estrogen-mediated repression requiring ERα.