TNFRSF13C polyclonal antibody

TNF cytokine family member TALL-1 (also designated BAFF, zTNF4, THANK and BLYS) is a type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. TALL-1 has the ability to bind to three receptors, TACI, BCMA and BAFF-R, but unlike other TNF receptors, BAFF-R specifically binds only the TALL-1 ligand. The gene encoding human BAFF-R, which maps to chromosome 22q13.1-q13.31, is expressed at high levels in spleen and lymph nodes and at lower levels in peripheral blood leukocytes and thymus. Expression of BAFF-R is crucial for selecting transitional B cells into the mature B cell pool.