TGIF2LY polyclonal antibody

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species. It also functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and control of gene expression. TGIF2LY (TGFB-induced factor homeobox 2-like, Y-linked), also known as TGIFLY, is a 185 amino acid testis-specific nuclear protein that functions as a transcriptional regulator during spermatid maturation. TGIF2LY belongs to the TALE/TGIF homeobox family and contains one homeobox DNA-binding domain. The gene encoding TGIF2LY maps within a male specific region of chromosome Y, in a region implied to form following a large X-to-Y transposition. The C-terminal region of TGIF2LY differs from the C-terminal region of its chromosome X homolog TGIF2LX, which suggests that TGIF2LY may act as a competitor or regulator of TGIF2LX.