CEACAM6 polyclonal antibody

The CD66 (carcinoembryonic antigen, CEA, Biliary glycoprotein I, BGP-1, CECAM) immunoglobulin superfamily of genes encode cell adhesion proteins, which are expressed at higher levels in tumorous tissues than in normal tissues . CD66 mRNA is strongly expressed in primary colon tumors and, to a lesser extent, in normal colonic tissue . The human CD66 gene family is a diverse set of glycoproteins of epithelial and hematopoietic lineage that comprises 29 genes, which map to chromosome position 19q13.1-q13.2. . CD66a, CD66b, CD66c, CD66d, CD66e and CD66f are the best characterized CD66 antigens, and CD66a-d expression upregulates on the surface of granulocytes upon stimulation . CD66 isoforms mediate homotypic and heterotypic intercellular adhesion events independently of cell type .