MTNR1A polyclonal antibody

Melatonin (Mel), a hormone secreted by the pineal gland, is expressed at night in response to the circadian clock . Melatonin is thought to be involved in regulating reproductive physiological development and the progression of sexual maturation, and it is also thought to play a role in tumorigenesis . The melatonin receptors, MEL-1A-R and MEL-1B-R, are members of the super-family of guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. Signaling through the melatonin receptors inhibits adenylate cyclase and stimulates phospholipase Cb upon activation of pertussis toxin (PTX)-sensitive G proteins. MEL-1A-R may be involved in pacing the biological clock. However, both MEL-1A-R and MEL-1B-R are implicated in controlling cellular growth in response to melatonin .