GPR85 polyclonal antibody

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways.G protein-coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules,such as hormones and neurotransmitters. GPR85 (G protein-coupled receptor 85), also designated SREB2 (super conserved receptor expressed in brain 2), is a 370 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR family. Highly expressed in testis and brain, GPR85 is found at lower levels in spleen, placenta and small intestine, and is encoded by a gene that maps to human chromosome 7q31.