EPX polyclonal antibody

Eosinophil peroxidase (EPX) is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX-dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies, cancer, and parasitic/helminthic infections. Human EPX gene product can form a tetramer of two light chains and two heavy chains. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK-dependent manner. Other peroxidase family members include myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO).