HSPBAP1 polyclonal antibody

HSPBAP1 (HSPB (heat shock 27kDa) associated protein 1), also known as PASS1 (protein associated with small stress protein 1), is a 488 amino acid cytoplasmic protein that contains one JMJC (Jumonji C) domain and shares 80% identity with its rat homolog, PASS1. Widely expressed with highest expression in ovary, thymus and pancreas, HSPBAP1 is thought to play a role in mediating cellular stress responses within the cell. Due to the presence of a JMJC domain, HSPBAP1 may be involved in chromatin remodeling events. Defects or translocations in the gene encoding HSPBAP1 are associated with renal cell carcinoma 1 (RCC1), suggesting a possible role for HSPBAP1 in carcinogenesis. Three isoforms of HSPBAP1 exist due to alternative splicing events.