PRL polyclonal antibody

Protein tyrosine phosphatases (PTPs) play a role in regulating diverse cellular processes. They form a small class of prenylated protein phosphatases called PRL proteins characterized by a C-terminal consensus sequence for prenylation. PRL-1, also designated Protein tyrosine phosphatase type IVA protein 1 (PTP4A1), is a unique nuclear PTP that is induced in regenerating liver and mitogen-stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. PRL-2 (Protein tyrosine phosphatase type IVA protein 2, or PTP4A2) is ubiquitously expressed with highest levels in heart, skeletal muscle and thymus but is also overexpressed in prostate tumor tissue. PPRL-2 is stimulates progression from G1 into S phase during mitosis and promotes tumors. PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3) is expressed in heart and skeletal muscle as well as epithelial cells of the small intestine and associates with the cell plasma membrane. Over expression of PRL-3 inhibits angiotensin-II induced cell calcium mobilization and promotes cell growth. PRL-3 is important for colorectal cancer metastasis and may serve as a new therapeutic target for this condition.