IL2RA polyclonal antibody

The IL-2 receptor is amulticomponentcomplexconsisting of three subunits,α,
β and γ, each ofwhich isrequired for high-affinity binding of IL-2. Theαchain
functions primarilyin binding IL-2, whereasthe β and γ chainscontribute to IL-2 binding and are essential to IL-2-induced activation ofsignaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinityligand-binding cytokine receptors. However, it is now well established that the IL-2Rγ chain functions as a second subunit of the high affinityIL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are nowreferred to asIL-4Rαand IL-7Rα, respectively,while the common subunit isreferred to as γc. Although the common γ chain enhancesligand binding in these three cytokine receptors, it has no capacityto bind these ligands on its own. There is evidence that the γcchain is also a subunit of IL-13R.